PHARMACY MCQ AND NPC EXAM DAILY SERIES 13

PHARMACY MCQ AND NPC EXAM DAILY SERIES  

PHARMACY MCQ AND NPC EXAM DAILY SERIES 

1. Which one of the followings is a plasminogen activator? 

(A) Tranexamic acid 

(B) Streptokinase

(C) Aminocaproic acid 

(D) None of the above 

2 Myasthenia gravis is diagnosed with improved neuromuscular function by 

using:

(A) Donepezil

(B) Edrophonium 

(C) Atropine 

(D) Pancuronium

3. Which one of the following drugs specifically inhibits calcineurin in the

activated T lymphocytes?

(A) Daclizumab 

(B) Prednisone

(C) Sirolimus 

(D) Tacrolimus

4. The chemical behaviour of morphine alkaloid is: 

(A) acidic 

(B)Basic 

(C) neutral 

(D) amphoteric

5. At physiological pH the following compound would be mostly in the:

(A) cationic form 

(B) unionized form 

(C) zwitterionic form 

(D) anionic form                                                                                                         

6. Which one of the followings is used as a mood stabilizer for bipolar disorder and also in certain epileptic convulsions? 

(A) Phenytoin 

(B) Lithium 

(C) Sodium valproate 

(D) Fluoxetine

7. An isosteric replacement for carboxylic acid group is: 

(A) pyrrole 

(B) isoxazole

(C) phenol 

(D) tetrazole

8.The given antibiotic is an example of ansamycins : 

(A) Roxythromycin 

(B) Adriamycin

(C) Aureomycin 

(D) Rifamycin

9.  For glyburide, all of the following metabolic reactions are logical except:

(A) O-demethylation 

(B) aromatic oxidation

(C) benzylic hydroxylation 

(D) amide hydrolysis 

10.  The effects observed following systemic administration of levodopa in the 

treatment of Parkinsonism have been attributed to its catabolism to dopamine. 

Carbidopa, can markedly increase the proportion of levodopa that crosses the blood brain barrier by:

(A) increasing penetration of levodopa through BBB by complexation with it 

(B) decreasing peripheral metabolism of levodopa 

(C) decreasing metabolism of levodopa in the CNS 

(D) decreasing clearance of levodopa from the CNS 

11. Ethambutol molecule has:

(A) two chiral centers and 3 stereoisomers

(B) two chiral centers and 4 stereoisomers

(C) two chiral centers and 2 stereoisomers

(D) one chiral center and 2 stereoisomers                                                                                                                           

12. A compound will be sensitive towards IR radiation only when one of the following properties undergo transition on: 

(A) Polarizability 

(B) Dielectric constant

(C) Dipole moment 

(D) Refractivity

13.  X-ray crystallographic analysis of an optically active compound determines its:

(A) Optical rotatory dispersive power 

(B) Absolute configuration

(C) Relative configuration 

(D) Optical purity

14. Which one of the following statements is wrong? 

(A) A singlet or triplet state may result when one of the electrons from the HOMO is excited to higher energy levels 

(B) In an excited singlet state, the spin of the electron in the higher energy orbital is paired with the electron in the ground state orbital 

(C) Triplet excited state is more stable than the singlet excited state

(D) When the electron from the singlet excited state returns to ground state, the molecule always shows fluorescence phenomenon 

15. Aminotransferases usually require the following for their activity :

(A) Niacinamide 

(B)Vitamin B12

(C) Pyridoxal phosphate 

(D) Thiamine

1. What is a plasminogen activator?

Plasminogen activators, such as Streptokinase, help break down blood clots by converting plasminogen to plasmin.

2. How is Myasthenia Gravis diagnosed?

It is diagnosed using Edrophonium, a short-acting acetylcholinesterase inhibitor that temporarily improves muscle strength.

3. Which drug inhibits calcineurin in activated T lymphocytes?

Tacrolimus inhibits calcineurin, preventing T-cell activation and is used as an immunosuppressant.

4. What is the chemical behavior of morphine?

Morphine is basic, as it contains an amine group that can accept protons.

5. What is the predominant form of drugs at physiological pH?

Most drugs exist in their cationic form at physiological pH (around 7.4), depending on their pKa.

6. Which mood stabilizer is used for bipolar disorder and epilepsy?

Lithium is used as a mood stabilizer for bipolar disorder, while sodium valproate is used for both epilepsy and mood stabilization.

7. What is an isosteric replacement for a carboxylic acid group?

Tetrazole is an isosteric replacement, commonly used in medicinal chemistry to mimic the function of carboxyl groups.

8. Which antibiotic belongs to the ansamycin class?

Rifamycin is an ansamycin antibiotic, used primarily for tuberculosis.

9. Which metabolic reaction is unlikely for glyburide?

Amide hydrolysis is unlikely, as glyburide mainly undergoes O-demethylation, aromatic oxidation, and benzylic hydroxylation.

10. How does carbidopa enhance levodopa's effectiveness in Parkinson’s disease?

Carbidopa decreases peripheral metabolism of levodopa, allowing more of it to reach the brain and reduce symptoms.

11. How many stereoisomers does ethambutol have?

Ethambutol has two chiral centers and four stereoisomers.

12. What property must a molecule have to be IR-active?

A molecule must have a dipole moment transition to absorb infrared radiation.

13. What does X-ray crystallography determine for optically active compounds?

It determines the absolute configuration of a molecule.

14. Which statement about singlet and triplet states is incorrect?

The incorrect statement is: "When the electron from the singlet excited state returns to the ground state, the molecule always shows fluorescence." Fluorescence is not always observed; other deactivation processes like internal conversion and quenching can occur.

15. Which coenzyme is required for aminotransferases to function?

Aminotransferases require Pyridoxal phosphate (Vitamin B6) as a cofactor.