PHARMACY MCQ AND NPC EXAM DAILY SERIES 8

               NPC EXAM DAILY SERIES

PHARMACY MCQ AND NPC EXAM DAILY SERIES

1. Metoclopramide is generally used for

(A) Prophylaxis of vomiting 

(B) Preventing motion sickness

(C) Treating irritable bowel syndrome

(D) Treatment of pancreatic insufficiency

2. DNA amplification by the polymerase chain reaction uses

(A) Thermus aquaticus DNA polymerase 

(B) DNA topoisomerase

(C) RNA polymerase 

(D) DNA helicase

3. Identify the non-pathogenic organism

(A) Mycobacterium bovis 

(B) Mycobacterium smegmatis

(C) Mycobacterium avium 

(D) Mycobacterium intracellulare

4. Bioassays are carried out to

(A) Measure the pharmacological activity of a drug

(B) Avoid clinical trails for new drugs

(C) Detect the impurity in a given drug

(D) Screen fro pharmacognetic influences of new drugs.

5. A direct way of studying idiosyncratic reactions to a given drug is by

(A) changing the route of drug administration

(B) changing the assay method

(C) pharmacogenomics

(D) structure activity relationship studies of a family of compounds

6. An example of haemopoietic growth factor is

(A) platelet derived growth factor 

(B) epidermal growth factor

(C) iron dextran 

(D) erythropoietin   

7. Safranin is used as a reagent to detect

(A) Gram-negative bacteria 

(B) Gram-positive bacteria

(C) Acid fast bacteria 

(D) Myxozoa

8. Sulphonamides do not have adverse drug interaction with

(A) Oral anticoagulants

(B) Sulfonylurea hypoglycemic agents 

(C) Hydantoin anticonvulsants

(D) Dihydrofolate reductase inhibitors

9. Simvastatin belongs to

(A) HMG CoA reductase inhibitor type of antilipidemic agents

(B) HMG CoA reductase inhibitor type of anticoagulant agents

(C) Fibrate type of anticoagulant agents

(D) Fibrate type of antilipidemic agents

10. HIV infection can be clinically controlled with

(A) Cytarabine 

(B) Acyclovir 

(C) Zidovudine 

(D) Amantadine

11. The measure of cohesive strength of the cross linking that occurs between gelatin molecules and is proportional to the molecular weight of gelatin is called

(A) Bloom strength 

(B) Viscosity

(C) Surface tension 

(D) Partition coefficient

12. A water soluble substance used as coating material in microencapsulation process is:

(A) Polyethylene 

(B) Silicone

(C) Hydroxy ethyl cellulose 

(D) Paraffin

13. One of the following is used as a solubilizing agent to solubilize testosterone in pharmaceutical liquid dosage forms.

(A) Sucrose monoesters 

(B) Lanolin esters

(C) Lanolin ethers 

(D) Tweens

14. One of the following is used as a pH dependent controlled release excipient.

(A) Carnauba wax

(B) Hydroxy proply methyl cellulose phthalate

(C) Methyl cellulose

(D) Glyceryl monostearate

15. The medicine should stored at coolmeans

(A). 2-8° C

(B). 8-25° C

(C). Below 0°C

(D). None  

Here’s the content in the requested format:

1. What is Metoclopramide used for?

Metoclopramide is generally used for the prophylaxis of vomiting (Option A). It helps in preventing nausea and vomiting, particularly in chemotherapy and post-surgery patients.

2. Which enzyme is used in DNA amplification by PCR?

The enzyme used in Polymerase Chain Reaction (PCR) is Thermus aquaticus DNA polymerase (Taq polymerase) (Option A). It remains stable at high temperatures, which is essential for DNA replication.

3. Which Mycobacterium species is non-pathogenic?

Mycobacterium smegmatis (Option B) is non-pathogenic and is often used in research as a model organism for studying tuberculosis.

4. What is the purpose of bioassays?

Bioassays are conducted to measure the pharmacological activity of a drug (Option A). They are used to determine potency and biological effects.

5. What is a direct way to study idiosyncratic drug reactions?

Pharmacogenomics (Option C) is used to study genetic variations that affect individual responses to drugs, including rare and unpredictable idiosyncratic reactions.

6. What is an example of a hematopoietic growth factor?

Erythropoietin (EPO) (Option D) is a hormone that stimulates red blood cell production and is used to treat anemia in patients with kidney disease or undergoing chemotherapy.

7. What is Safranin used to detect?

Safranin is used as a counterstain in Gram staining to detect Gram-negative bacteria (Option A).

8. Which drug class does NOT have adverse interactions with sulfonamides?

Dihydrofolate reductase inhibitors (Option D) do not have significant interactions with sulfonamides, unlike anticoagulants and hypoglycemic agents.

9. What class of drugs does Simvastatin belong to?

Simvastatin is an HMG CoA reductase inhibitor used as an antilipidemic agent (Option A). It lowers cholesterol levels and reduces cardiovascular risk.

10. Which drug is used to control HIV infection?

Zidovudine (AZT) (Option C) is a nucleoside reverse transcriptase inhibitor (NRTI) used to treat HIV infections by preventing viral replication.

11. What is Bloom strength in pharmaceuticals?

Bloom strength (Option A) measures the cohesive strength of gelatin in pharmaceutical formulations, particularly for capsule shells.

12. Which water-soluble substance is used for microencapsulation?

Hydroxyethyl cellulose (Option C) is commonly used as a coating material in the microencapsulation process.

13. What is used as a solubilizing agent for testosterone in liquid dosage forms?

Tweens (Polysorbates) (Option D) are commonly used as solubilizing agents to increase the solubility of testosterone in liquid formulations.

14. What is an example of a pH-dependent controlled-release excipient?

Hydroxypropyl methylcellulose phthalate (HPMCP) (Option B) is a pH-dependent excipient used in controlled-release formulations.

15. What does "cool storage" mean in pharmaceutical storage conditions?

"Cool storage" refers to a temperature range of 8-25°C (Option B). It is used for storing medications that require controlled temperatures to maintain stability.