PHARMACY MCQ AND NPC EXAM DAILY SERIES 10

PHARMACY MCQ AND NPC EXAM DAILY SERIES

PHARMACY MCQ AND NPC EXAM DAILY SERIES

1. To understand the drug receptor interaction is necessary to quantify the relation between:

(a) Drug and its toxicity 

(b) Drug and its absorption

(c) Drug and its biological effect 

(d) Drug and intermediate product

2. Penicillinase resistance penicillin is:

(a) Amoxycillin

(b) Amipicillin 

(c) Penicillin V 

(d) Methicillin

3. Morphine is present in:

(a) Atropa belladona

(b) Papaver somniferum

(c) Ricinus communis

(d) Solanum nigrum

4. Ion exchange chromatography is the method of choice for separation of:

(a) Metals 

(b) Sugar 

(c) Fatty acid 

(d) Sterols

5. Rideal Walker test is performed by using the strain: 

(a) Escherichia coli

(b) Straphylococcus neruri

(c) Straphylococcus pyrogenes

(d) Salmonella typhii     

6. Pheniramine maleate is an antihistaminic agent belonging to the class:

(a) Ethylenediamine derivative 

(b) Cyclic basic class analogs

(c) Aminoallyl ether analoges 

(d) None of the above

7. Tetracycline undergo epimerization C-4 between pH 4 and 8 to give:

(a) Isotetracyclines 

(b) Epitetracyclines

(c) Nortetracyclines 

(d) None of above

8. Tyndalisation means: 

(a) Successive autoclaving with a bactericide

(b) Successive heating with a bactericide

(c) Successive heating at low temperature

(d) Successive autoclaving at low temperature and incubator

9. Morphine and heroin differ from each other in respect of:  

(a) Mehyl group on nitrogen 

(b) Acetyl groups at C3 and C6

(c) Abesence of double bond between C4 and C6

(d) Absence of D ring

10. Vincristine and Vinblastine act by :

(a) Binding with the protein tubulin and arrest at metaphase

(b) Inhibiting the protein synthesis

(c) Acting as antimetabolite

(d) Inhibiting the enzyme system

11. A rhamno-glucoside on complete hydrolysis will give:

(a) Aglycon + Fructose + Rhamnose 

(b) Aglycon + Ribose + Rhamnose

(c) Aglycon + Rhamnose + Glucose 

(d) Rhamnose + Fructose

12. The technique employed to study the insoluble film at oil water interface is:

(a) Micellization 

(b) Defloculation

(c) Electrostatic balance 

(d) Film balance   

13. Gray baby syndrome is the side effect of:

(a) Streptomycin 

(b) Chloramphenicol

(c) Penicillin 

(d) Tetracycline

14. N,N dimethyl –(1-methyl-1-oxo-3,3-diphenylhexyl) ammonium chloride is the chemical:

(a) Methadone hydrochloride 

(b) Alpha proline hydrochloride

(c) Meperidine hydrochloride 

(d) Darvon

15. Sulphonamide tragedy was due to combination with:

(a) Penicillin 

(b) Streptomycin

(c) Diethylene hydrochloride 

(d) Bicarbonate

1. Why is it necessary to quantify the relationship between drug and its biological effect?

Understanding drug-receptor interactions helps determine the potency, efficacy, and safety of a drug in treating diseases.

2. Which penicillin is resistant to penicillinase?

Methicillin is a penicillinase-resistant penicillin, designed to resist bacterial beta-lactamases.

3. Which plant contains Morphine?

Morphine is present in Papaver somniferum (Opium poppy).

4. What is the preferred method for separating metals in a sample?

Ion exchange chromatography is used for the separation of metals.

5. What is the Rideal-Walker test used for?

It is performed using Staphylococcus pyogenes to determine the phenol coefficient, a measure of disinfectant efficacy.

6. To which class does Pheniramine maleate belong?

Pheniramine maleate is an antihistaminic drug, but it does not belong to ethylenediamine or aminoalkyl ether classes.

7. What happens to tetracycline between pH 4 and 8?

It undergoes epimerization at C-4, forming epitetracyclines, which are less active.

8. What is Tyndallization?

It is a successive heating at low temperatures to eliminate bacterial spores in sterilization.

9. How do Morphine and Heroin differ?

Heroin differs from Morphine due to acetyl groups at C3 and C6, making it more lipophilic and potent.

10. How do Vincristine and Vinblastine work?

They bind to tubulin, preventing microtubule formation and arresting the cell cycle at metaphase, making them effective anti-cancer drugs.

11. What is obtained from the complete hydrolysis of a rhamno-glucoside?

The hydrolysis yields Aglycon + Rhamnose + Glucose.

12. Which technique is used to study insoluble films at the oil-water interface?

Film balance is used to study insoluble films at the oil-water interface.

13. What is Gray Baby Syndrome, and which drug causes it?

Gray Baby Syndrome is a toxic reaction due to chloramphenicol, causing cyanosis, vomiting, and circulatory collapse in newborns.

14. What is the chemical name of Methadone hydrochloride?

Methadone hydrochloride is chemically known as N,N dimethyl-(1-methyl-1-oxo-3,3-diphenylhexyl) ammonium chloride.

15. What caused the Sulfonamide tragedy?

The Sulfonamide tragedy was due to its combination with diethylene glycol, a toxic solvent, causing multiple deaths.