MEDICINAL CHEMISTRY MCQ AND NPC EXAM DAILY SERIES 28

 NPC MCQ  DAILY PRACTICE

[MEDICINAL CHEMISTRY]

1. Body mass index is calculated as: 

A. weight in pounds by height in meters 

B. weight in kg by height in meters 

C. weight in kg divided by square of height in meter squared 

D. weight in kg divided by body surface area

2. The body fluid compartment that contains more osmotically active particles (in relation to other fluid compartments in the same individual) is: 

A. intracellular fluid 

B. plasma 

C. interstitial fluid 

3. In a healthy adult, ECF volume constitutes, what fraction of body weight? 

A. 10% 

B. 20% 

C. 30% 

D. 40% 

4. In a healthy adult male weighing 70 kg, the total volume of fluid present in the transcellular compartment does not normally exceed: 

A. 1 liter 

B. 3 liters 

C. 5 liters 

D. 7 liters 

5. Which of the following markers administered intravenously distributes exclusively in intracellular fluid? 

A. Evans blue dye 

B. Heavy water 

C. Sucrose 

D. None of the above 

6. Which of the following substances can be  used as a marker for the ECF compartment? 

A. Nonmetabolizable sugars 

B. Glucose 

C. Radio-iodinated albumin 

D. D2O 

7. What fraction of total body potassium is present in plasma? 

A. 0.4% 

B. 8.2% 

C. 12% 

D. 88% 

8. Which of the following solutions is 

hypertonic? 

A. 0.9 % NaCl 

B. 5% dextrose 

C. 20% mannitol 

D. Distilled water 

9. Sodium-glucose cotransport in the intestine and kidney is an example of: 

A. primary active transport 

B. secondary active transport 

C. facilitated diffusion 

D. passive transport 

10. Which of the following is an example of passive transport? 

A. Calcium efflux by calcium pump 

B. Na-Ca exchanger 

C. Potassium efflux through potassium leak channels 

D. Calcium sequestration in sarcoplasmic reticulum 

11. How many subunits do G proteins have? 

A. One 

B. Two 

C. Three 

D. Four 

12. Which subunit of G proteins has intrinsic GTPase activity? 

A. Alpha 

B. Beta 

C. Gamma 

D. Delta 

13. Which of the following hormones does not act via a G-protein coupled receptor in the cell membrane? 

A. Thyrotropin releasing hormone 

B. Angiotensin II 

C. Antidiuretic hormone 

D. Thyroxine 

14. Which toxin inhibits the function of Gi? 

A. Cholera toxin 

B. Pertussis toxin 

C. Forskolin 

D. Saxitoxin 

15. Which receptor does not span the cell membrane seven times? 

A. Rhodopsin 

B. Beta-adrenergic receptor 

C. Insulin receptor 

D. M2 receptor 

1. How is Body Mass Index (BMI) calculated?

BMI is calculated as weight in kg divided by the square of height in meters (kg/m²).

2. Which body fluid compartment has the highest number of osmotically active particles?

The intracellular fluid (ICF) contains the most osmotically active particles compared to plasma and interstitial fluid.

3. What fraction of body weight is made up of extracellular fluid (ECF)?

ECF accounts for 20% of body weight in a healthy adult.

4. What is the total volume of fluid in the transcellular compartment of a 70 kg adult male?

The transcellular fluid compartment typically contains less than 1 liter of fluid.

5. Which markers can be used to measure the intracellular fluid (ICF) compartment?

None of the commonly used markers distribute exclusively in the intracellular fluid.

6. What markers are used to measure extracellular fluid (ECF)?

Nonmetabolizable sugars such as inulin and mannitol are commonly used markers for ECF.

7. What percentage of total body potassium is found in plasma?

Only 0.4% of total body potassium is present in plasma.

8. Which of the following is a hypertonic solution?

20% Mannitol is a hypertonic solution.

9. What type of transport is sodium-glucose cotransport?

It is an example of secondary active transport, where sodium movement drives glucose uptake.

10. What is an example of passive transport?

Potassium efflux through potassium leak channels occurs via passive transport.

11. How many subunits do G-proteins have?

G-proteins consist of three subunits (α, β, and γ).

12. Which G-protein subunit has intrinsic GTPase activity?

The alpha (α) subunit has intrinsic GTPase activity.

13. Which hormone does not act via a G-protein coupled receptor?

Thyroxine (T4) does not act via a G-protein coupled receptor; it acts via an intracellular receptor.

14. Which toxin inhibits the function of Gi protein?

Pertussis toxin inhibits the function of Gi protein by preventing it from inhibiting adenylate cyclase.

15. Which receptor does not span the membrane seven times?

The insulin receptor does not span the membrane seven times; it is a tyrosine kinase receptor.